• Introduction the DNA damage response

  2023-02-10

  

  Introduction: the DNA damage response — important implications for tumour development and treatment Cells are invariably challenged by tens of thousands of lesions inflicted on their DNA everyday (Lindhal, 1993). This DNA damage can be caused exogenously by exposure to different types of radiation

• br Experimental section br Acknowledgements br Introduction

  2023-02-10

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming TCS 2510 in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correlated wi

• br Materials and methods br Acknowledgement

  2023-02-10

  

  Materials and methods Acknowledgement This work was supported by the Beijing Natural Science Foundation (Grant no. 6151001), and the National Natural Science Foundation of China (Grant no. 31572516). Introduction Staphylococcus aureus is an important microorganism responsible for both clin

• According to the present observations

  2023-02-10

  

  According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters a66 of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26], [37]. AP-1 modulate

• MADS box proteins are combinatorial transcription factors in

  2023-02-10

  

  MADS box proteins are combinatorial transcription factors in that they often derive their regulatory specificity from other DNA binding or accessory factors. In many cases, the cofactor with which MADS box proteins interact specifies which genes are regulated, when they are regulated and if these ge

• Introduction The burden of cardiovascular disease

  2023-02-10

  

  Introduction The burden of cardiovascular disease (CVD) is undisputed, accounting for approximately a third of global deaths (17.5 million people in 2012) (WHO, 2012). Atherosclerosis leads to the development of coronary heart disease (CHD) which accounts for more than 40% of these deaths (WHO, 201

• Circular dichroism CD provides useful information about prot

  2023-02-10

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light JNJ-1661010 spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonl

• Interestingly our transgenic mouse model with macrophages ex

  2023-02-08

  

  Interestingly, our transgenic mouse model with macrophages expressing AdipoR1 showed not only improved insulin sensitivity and inflammation in skeletal muscle and adipose tissues, but fat mass, macrophage and plasma lipid accumulation and foam cell formation was also favorably reduced resulting from

• To investigate further the clinical and mutational spectrum

  2023-02-08

  

  To investigate further the clinical and mutational spectrum associated with -related dyskinesia, we here performed a screen in a large series of patients affected with an unexplained hyperkinetic movement disorder, resulting in the identification of 2 pediatric patients presenting with a novel pheno

• br Methods br Results br Discussion First

  2023-02-08

  

  Methods Results Discussion First, the rb 1 isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed that treatment w

• In pioneering work from Ikeda and

  2023-02-08

  

  In 2006, pioneering work from Ikeda and colleagues showed that GMF localizes to and regulates the BW 723C86 hydrochloride cytoskeleton (see Glossary), and noted its sequence similarity to ADF/cofilin[11]. In 2009, the structure of GMF [6] was solved, revealing it to be a bona fide member of the acti

• As also found by Stolarski et al inclusion

  2023-02-08

  

  As also found by Stolarski et al. [14], inclusion of N2O in the model is successful in reducing the effect of dynamics [13] in the lower stratosphere in the Northern Hemisphere (30–60°N in our case). The inclusion of N2O also decreased the error bars on the trend values, but the trend values still c

• mao inhibitors The structure of LO is divided in two

  2023-02-08

  

  The structure of 5-LO is divided in two domains, the catalytic C-terminal domain and the N-terminal regulatory C2-like domain (C2ld) [59,60]. The C2ld spans the mao inhibitors 1-114 and is responsible for translocation and binding of calcium and membranes [61–63]. The catalytic domain is primarily

• Introduction Dementia is a common

  2023-02-08

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• Bacitracin br Introduction Cadmium is a major component of

  2023-02-08

  

  Introduction Cadmium is a major component of heavy metal pollution. Phytoremediation is considered to be the more effective method for recovering contaminated soil [[1], [2], [3], [4]] via cadmium absorption, transport, and accumulation. Several cadmium-associated proteins have previously been we

16726 records 358/1116 page Previous Next First page 上5页 356357358359360 下5页 Last page