• Echinocandin resistance is systematically associated

  2024-11-11

  

  Echinocandin resistance is systematically associated with point mutations in either FSK1 or FSK2 genes [7], [104]. These mutations are located in two different not spot regions of these genes named HS1 and HS2. Hot spot mutations have been reported in C. albicans, C. glabrata, C. tropicalis, C. krus

• Therefore in the present study we

  2024-11-11

  

  Therefore, in the present study, we first examined the ATRAP BADGE in human leukocytes of healthy subjects. We next analyzed possible relevant clinical factors affecting ATRAP expression in leukocytes of patients with NCDs. Furthermore, we examined the possible effect of ATRAP downregulation on the

• The Nagoya Heart Study enrolled patients with hypertension a

  2024-11-11

  

  The Nagoya Heart Study enrolled patients with hypertension and type 2 diabetes or impaired Azithromycin Dihydrate tolerance (12). Patients were randomized to valsartan- or amlodipine-based regimens with a BP target of ≤130/80 mmHg. The primary outcome was a composite of sudden cardiac death, myocar

• br Disclosure br Acknowledgments br Introduction Deeper

  2024-11-11

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small 96 4 that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal growth

• The aldehyde reductase AKR A and aldose reductase AKR B

  2024-11-11

  

  The aldehyde reductase (AKR1A1) and aldose reductase (AKR1B1) belong to aldo-ketoreductase (AKR) superfamily catalyzing the reduction of corresponding aldehydes and ketones involved. Both the closely related enzymes AKR1A1 and AKR1B1 have 65% structural similarity and differ only at the active site.

• cell proliferation kit br AD and COX LOX pharmacology

  2024-11-09

  

  AD and COX/5-LOX pharmacology Early studies on the role of cyclooxygenases in AD were inspired by epidemiological data suggesting that COX inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs) could be beneficial in AD patients (Lucca et al., 1994, McGeer et al., 1990). This line of re

• Inhibitors of mPGES are considered as

  2024-11-09

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• br Conclusion The HT receptor family is complex and one

  2024-11-09

  

  Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless simvastatin zocor receptor (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function);

• Materials and methods br Results br Discussion ATX plays

  2024-11-09

  

  Materials and methods Results Discussion ATX plays a significant role in initiating and sustaining tumor metastasis [43]. LPA stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor Phosphate Colorimetric As

• br Diabetes and obesity fit or fat sugar

  2024-11-09

  

  Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased cyclin dependent kinase inhibitor production, rise in adi

• In the present study we sought to

  2024-11-09

  

  In the present study we sought to decipher the role of ATP-citrate lyase and of the mitochondrial NADH-dependent Mae in the oleaginous yeast Y. lipolytica. Indeed, although this yeast is one of the major models for lipid metabolism, the function of these enzymes is still not clear. As the study of t

• Isochlorogenic acid A mg The use of FTAI can overcome the ne

  2024-11-09

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable Isochlorogenic acid A mg follicle. Pregnancy rates obtained with FTAI may be comparable or better than those

• In the pituitary of R quelen mRNA levels

  2024-11-09

  

  In the pituitary of R. quelen mRNA levels of cyp19a1b were found to be higher in males than females, suggesting a sex-specific function, and perhaps a local action to regulate gonadotropins or other pituitary hormone secretion (Olivereau and Callard, 1985; Zhang et al., 2014). Interestingly, the hig

• br Materials and methods br Results br Discussion

  2024-11-09

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by Taxifolin neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and ROS-m

• Numerous investigators have shown that RACK

  2024-11-09

  

  Numerous investigators have shown that RACK1 has several important, possibly related, roles in mRNA splicing and in translation. RACK1 interacts directly with specific components of the 40S ribosomal subunit (specifically, the 18S rRNA and ribosomal proteins rpS16e, rpS17e, and rpS3e [new names: uS9

16719 records 65/1115 page Previous Next First page 上5页 6162636465 下5页 Last page